Carcinoma Mucoepidermoide de Glándulas Salivales Intraoral: Factores Clínicos y Patológicos e Inmunoexpresión de c-erbB-2 en 29 Casos. Vanessa Fátima. Publisher: El propósito de este estudio es presentar la casuística del carcinoma mucoepidermoide de glándulas salivales de pacientes diagnosticados en el. English: Tumors of the salivary glands represent % of head and neck neoplasms. Mucoepidermoid carcinoma (MEC) is the most common epithelial.
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Carcinoma mucoepidermoide de glándulas salivales en Brasil: relación clinicopatológica
Sinonasal and maxillary tumors were not included in this study as intraoral salivary gland tumors since that in these zalivales mucoepidermoid carcinoma presents different origin rather than glandular Ellis et al. Data regarding the positivity for c-erbB-2 on salivary gland tumors are very variable. In situ intraductal carcinoma of the breast was used as a c-erbB-2 positive control and negative controls were obtained by the omission of the primary antibody.
For this study only the intraoral MEC surgically treated with adequate material for microscopic and immunohistochemical analysis corresponding to 29 cases were analyzed. Clinical information about age, gender, and site were obtained from the biopsy records.
Histopathologic grading of salivary gland neoplasms. Surgical Pathology ofthe salivary glands. HER2 expression in salivary gland carcinomas: Surgical resection was performed in all patients.
The mucoepidermoid carcinoma generally shows an extremely aggressive pattern for high-grade tumors, whereas its respectivee low-grade counterpart is often indolent and slow-growing. The clinicopathologic features and results of log rank tests for clinical variables are shown in tables 1 and 2respectively. Review of the literature and clinicopathological analysis of 18 patients.
The association among clinicopathological features and c-erbB-2 oncoprotein expression was evaluated in twenty-nine cases of intra-oral mucoepidermoid carcinoma MEC.
Clinicopathologic and immunohistochemical study of intraoral mucoepidermoid carcinoma. The follow-up period in this study ranged from 6 to months.
From oral biopsies submitted during period between and ,40 0. High grade tumors, on the other hand, seem to arise more often in major salivary glands Kokemueller et al. Microscopically, 27 cases There lgandulas a wide variation in these malignant neoplasms over different geographic areas and ethnic groups.
Inmunostaining for ki67 were made.
Users should refer to the original published version of the material for the full abstract. Rare expression of the c-erbB-2 oncoprotein in salivary gland tumors: Mucoepidermoid carcinoma of the salivary glands. Evaluation and application of grading criteria in cases. The c-erbB-2 oncoprotein is involved in matrix degradation and walivales activity as well as in the increase in vessel permeability, endothelial cell growth, proliferation, migration, and differentiation Ccarcinoma et al. Mucoepidermoid carcinoma of intraoral salivary glands.
Briefly, 4 um sections were dewaxed in xylene and hydrated with graded ethanol. The tumoral histological grade was associated with the ki67 expression, relevant prognosis factors in MEC. However, there are few articles with a significative number of cases Lopes et al. Studies on intra-oral MEC have shown similar results with a higher percentage of low grade tumors Kokemueller et al. Evaluation and application of grading criteria in cases. International Journal of Morphology.
However, its prognostic value should be validated with clinical studies and survival analyses. However, other studies reported a rare expression of c-erbB-2 on these tumors Kernohan et al.
Intraoral mucoepidermoid carcinoma of salivary glands. Further investigation of potential factors that may influence the survival of these patients should be encouraged through longer follow-up periods and larger samples. This antibody although less sensitive than the polyclonal antibody used in other reports Lopes et al. Remote access to EBSCO’s databases is permitted to patrons of subscribing institutions accessing from remote locations for personal, non-commercial use.
In contrast to results reported by Nance and others 4 in present study was not observed any association between positive surgical margins and decreased DFS. This study aimed to investigate prognostic factors that may affect survival in patients with a primary diagnosis of head and neck mucoepidermoid carcinomas.
Unlike other studies that used this same grading system, 4,13 the results demonstrate a balance in distribution among the three tumor grades subtypes.
Most of the studies show that the palate is the most common site of ocurrence Lopes et al. Mucoepidermoid carcinoma MEC is the most common malignant neoplasm of major and minor salivary glands Lopes et al, Tumors were more common in the third and fourth decades of life Mucoepidermoid carcinoma of the head and neck: The Kaplan-Meier method was used to plot survival curves with the log rank test for analysis of cumulative survival rates.
The OS was defined as the interval between the beginning of the treatment and the date of death or last information for censored observations. Considering the results in the appraised sample, our findings suggest that some mucoepidermoid carcinoma overexpress c-erbB-2 independent of clinicopathological features such as patient age and gender and site or histological grades of the lesions.
Selecting antibodies to detect HER2 overexpression by immunohistochemistry in invasive mammary carcinomas. A total of 16 cases were analyzed over a period of 18 years; males were Concerning MEC, there had been only individual case descriptions of c-erbB-2 expression Kernohan et al.
However, as the MEC is the most common malignant tumor of salivary glands in young people this observation is in accordance with the literature as also the female predilection Auclair et al.
Mucoepidermoid carcinoma of the salivary glands in Brazil: