Biosynthesis of digitoxin in Digitalis purpurea []. Deluca, M.E. Seldes, A.M. Gros, E.G. (Departamento de Quimica Organica, Universidad de Buenos Aires. Download Citation on ResearchGate | Biosynthesis of digitoxin in Digitalis purpurea | Simultaneous administration of a mixture of [H]-3β. Deluca M.E.; Seldes A.M.; Gros E.G., Biosynthesis of digitoxin in digitalis purpurea.
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Biosynthesis of digitoxin in digitalis purpurea. Antidigoxin antibody fragments, the specific treatment for digoxin poisoning, are also effective in serious digitoxin toxicity.
Comparative study of the biology of digitalis lanata digitalis ambigua digitalis purpurea and a digitalis purpurea inoculated population. Biosynthesis of digitalis glycosides. Studies on the production of Digitalis cardenolides by plant tissue culture.
Determination of digitoxin and other glycosides and genins in Digitalis purpurea. Khimiko-Farmatsevticheskii Zhurnal 5 Incidence and biosynthesis of cardenolides in tissue cultures of Digitalis purpurea and Digitalis lanata.
Transl9 5 European Journal of Clinical Investigation. Planta Medica 29 3: It is a phytosteroid and is similar in structure and effects to digoxin though the effects are longer-lasting. Unlike digoxin which is eliminated from the body via the kidneysit is eliminated via the liver, so could be used in patients with poor or erratic kidney function.
This page was last edited on 20 Septemberat Ouabain g-Strophanthin k-Strophanthin Cymarin. Ceskoslovenska Farmacie 2 Chemistry of natural compounds: Digitoxin exhibits similar toxic effects to the more commonly used digoxinnamely: Journal of Pharmacy and Pharmacology 8 International Journal of Clinical Pharmacology and Therapeutics. Alcoholic glycoside Cardiac glycoside Bufadienolide Cardenolide Cyanogenic glycoside Glycosylamine Phenolic glycoside Anthraquinone glycoside Coumarin glycoside Flavonoid glycoside Saponin Steviol glycoside Thioglycoside.
While several controlled trials have shown digoxin to be effective in a proportion of patients treated for heart failure, the evidence base for digitoxin is not as strong, although it is presumed to be similarly effective.
Planta Medica 46 2: Retrieved from ” https: Studies in digitoxij genus Digitalis. The modern therapeutic use of this molecule was made possible by the works of the pharmacist and the French chemist Claude-Adolphe Nativelle Biotransformation of digitoxin by suspension callus culture of Digitalis purpurea.
Biosynthesis of digitoxin in Digitalis purpurea
Digitoxin is a cardiac glycoside. Digitoxin and related cardenolides display potent anticancer activity against a range of human cancer cell lines in vitro but the clinical use of digitoxin to treat cancer has been restricted by its narrow therapeutic index. Determination of the digitoxin content of Digitalis purpurea. Quantitative determination of digitoxin and gitoxin in the leaves of Digitalis purpurea.
Views Read Edit View history. Oswald Schmiedeberg was able to obtain a pure sample digitoxij Comparative investigation of the biology of Digitalis lanata, Digitalis ambigua, Digitalis purpurea and Digitalis purpurea grafted population.
The first structural analysis was od by Adolf Otto Reinhold Windaus inbut the full structure with an exact determination of the sugar groups was not accomplished until Cardenolides in surface-cultures of cotyledones and leaves of Digitalis purpurea. Industrial hiosynthesis tests of medicinal plants vi purple digitalis d digitalis purpurea d digitoxin glucoside.
Planta Medica 17 4: However, it is now rarely used in current Western medical practice. Effects of nutrients on digitoxin formation by shoot-forming cultures of Digitalis purpurea L.
Annales Pharmaceutiques Francaises 25 O-glycosidic bond N-glycosidic bond S-glycosidic bond C-glycosidic bond. Bufo Arenobufagin Bufotalin Cinobufagin Marinobufagin. Quantitative determination of digitoxin and gitoxin in digitalis purpurea.
The Yale Journal of Biology and Medicine. Studies on the production of digitalis cardenolides by plant tissue culture 3. From Wikipedia, the free encyclopedia. Arenobufagin Bufotalin Cinobufagin Marinobufagin.
Biosynthesis of digitoxin in Digitalis purpurea [1989]
Cardiac glycosides and cancer therapy”. With Practical Remarks on Dropsy and other Diseases.
Plant biosynrhesis Cell Physiology 23 7: Enzymatic glucosylation of digitoxin by particle enzyme fractions of Digitalis purpurea. In other projects Wikimedia Commons. Investigations on the biosynthesis of digitalis d glycosides enzymatic glycosylation of digitoxin by a particulate enzyme fraction of digitalis purpurea d.
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